An inhibitor of FAF1
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KR-33493

Item No. 22071

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[2-[(4-bromophenyl)thio]acetyl]amino]-1-(2-phenylethyl)-1H-pyrazole-3-carboxylic acid
CAS Number
1021497-97-1
Molecular Formula
C20H18BrN3O3S
Formula Weight
460.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: ~10mg/mL
λmax
256 nm
SMILES
BrC1=CC=C(SCC(NC2=CN(CCC3=CC=CC=C3)N=C2C(O)=O)=O)C=C1
InChi Code
InChI=1S/C20H18BrN3O3S/c21-15-6-8-16(9-7-15)28-13-18(25)22-17-12-24(23-19(17)20(26)27)11-10-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2,(H,22,25)(H,26,27)
InChi Key
ZRLJEHIUGYTTSZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $107

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    5 mg

    $451

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    10 mg

    $794

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    25 mg

    $1,319

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    Product Description

    KR-33493 is an inhibitor of Fas-associated factor 1 (FAF1).1,2 It inhibits chemical hypoxia-induced apoptosis in H9c2 cardiomyocytes and hydrogen peroxide-induced cell death in SH-SY5Y cells when used at a concentrations of 10 and 20 μM, respectively.2,3 KR-33493 (20 mg/kg per day) reduces decreases in striatal dopamine transporter activity in a mouse model of Parkinson's disease induced by MPTP.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Park, H.S., Moon, B.S., Yoo, S.-E., et al. Assesment of potential protective effect on dopaminergic neuron by an Fas-associated factor 1 inhibitor treatment using [18F]FE-PE2I PET in a Parkinson’s disease mouse model. J. Nucl. Med. 58(Suppl 1), 13 (2017).

    2. Yoo, S.-e., Yu, C., Jung, S., et al. Design and synthesis of fluorescent and biotin tagged probes for the study of molecular actions of FAF1 inhibitor. Bioorg. Med. Chem. Lett. 26(4), 1169-1172 (2016).

    3. Jung, Y.-S., Kim, E., Kim, N., et al. Aminopyrazole derivatives, process for the preparation thereof, and composition for preventing or treating ischemic diseases containing the same. WO 2008/051047 Al, (2008).