A selective agonist of mGluR8
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DCPG (hydrochloride)

Item No. 22072

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(S)-aminocarboxymethyl]-1,2-benzenedicarboxylic acid, hydrochloride
Synonyms
  • (S)-3,4-DCPG
Molecular Formula
C10H9NO6 • XHCl
Formula Weight
239.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 33 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(O)C1=C(C(O)=O)C=CC([C@H](N)C(O)=O)=C1.Cl
InChi Code
InChI=1S/C10H9NO6.ClH/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15;/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17);1H/t7-;/m0./s1
InChi Key
QUMMBISGFDASGN-FJXQXJEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $135

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    10 mg

    $219

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    Product Description

    DCPG is a selective agonist of the class III metabotropic glutamate receptor 8 (mGluR8), with an EC50 value of 31 nM for inhibiting forskolin-stimulated cAMP formation in AV12-664 cells expressing human mGluR8.1 It is selective for mGluR8 over other mGluRs (EC50s = >3.5 µM for mGluR1-7). In vitro, DCPG (1 μM) inhibits the responses of mouse retinal ganglion cells to the withdrawal of both bright and dim light stimuli by 68-69% relative to untreated cells.2 In vivo, DCPG (10 nmol, i.c.v.) reverses catalepsy induced by prolonged exposure to haloperidol (Item No. 12014) in a rat model of Parkinson's disease.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thomas, N.K., Wright, R.A., Howson, P.A., et al. (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology 40(3), 311-318 (2001).

    2. Reed, B.T., Morgans, C.W., and Duvoisin, R.M. Differential modulation of retinal ganglion cell light responses by orthosteric and allosteric metabotropic glutamate receptor 8 compounds. Neuropharmacology 67, 88-94 (2013).

    3. Johnson, K.A., Jones, C.K., Tantawy, M.N., et al. The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson’s disease. Neuropharmacology 66, 187-195 (2013).