An internal standard for the quantification of decitabine
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Decitabine-15N4

Item No. 22091

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(amino-15N)-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one-1,3,5-15N3
Synonyms
  • 5-aza-2’-Deoxycytidine-15N4
  • DAC-15N4
Molecular Formula
C8H12[15N]4O4
Formula Weight
232.2
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly, heated
SMILES
O[C@H]1C[C@H]([15N]2C=[15N]C([15NH2])=[15N]C2=O)O[C@@H]1CO
InChi Code
InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1/i9+1,10+1,11+1,12+1
InChi Key
XAUDJQYHKZQPEU-SSDNLDPUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $502

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    Product Description

    Decitabine-15N4 is intended for use as an internal standard for the quantification of decitabine (Item No. 11166). Decitabine is a 2’-deoxy analog of 5-azacytidine (Item No. 11164) that induces dose-dependent inhibition of DNA methyltransferases and hypomethylation of DNA.1,2,3 This action is useful in conditions characterized by DNA hypermethylation, as is found in myelodysplastic syndromes.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Esteller, M. Epigenetics in cancer. N. Engl. J. Med. 358(11), 1148-1159 (2008).

    2. Lyko, F., and Brown, R. DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J. Natl. Cancer Inst. 97(20), 1498-1506 (2005).

    3. Stresemann, C., Brueckner, B., Musch, T., et al. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 66(5), 2794-2800 (2006).

    4. Ornstein, M.C., and Sekeres, M.A. Combination strategies in myelodysplastic syndromes. Int. J. Hematol. 95(1), 26-33 (2012).