An oxidative metabolite of bexarotene
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Parent Compound(s)
11571Bexarotene
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6-hydroxy Bexarotene

Item No. 22098

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[1-(5,6,7,8-tetrahydro-6-hydroxy-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-benzoic acid
CAS Number
368451-07-4
Molecular Formula
C24H28O3
Formula Weight
364.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 10 mg/mlEthanol: 0.5 mg/ml
λmax
204, 264 nm
SMILES
CC(C(C(C1=CC=C(C(O)=O)C=C1)=C)=C2)=CC3=C2C(C)(C)CC(O)C3(C)C
InChi Code
InChI=1S/C24H28O3/c1-14-11-20-19(23(3,4)13-21(25)24(20,5)6)12-18(14)15(2)16-7-9-17(10-8-16)22(26)27/h7-12,21,25H,2,13H2,1,3-6H3,(H,26,27)
InChi Key
WTWGVKDCAJSUBZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    6-hydroxy Bexarotene is an oxidative metabolite of bexarotene (Item No. 11571), a high-affinity ligand for retinoid X receptors (RXRs).1 6-hydroxy Bexarotene binds to RXRα, RXRβ, and RXRγ as well as retinoic acid receptor α (RARα; Kds = 3.46, 4.21, 4.83, and 8.17 μM, respectively). It selectively activates RXRα, RXRβ, and RXRγ over RARα, RARβ, and RARγ in vitro (EC50s = 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Howell, S.R., Shirley, M.A., Grese, T.A., et al. Bexarotene metabolism in rat, dog, and human, synthesis of oxidative metabolites, and in vitro activity at retinoid receptors. Drug Metab. Dispos. 29(7), 990-998 (2001).