An internal standard for the quantification of apigenin
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Apigenin-d5

Item No. 22106

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-dihydroxy-2-(4-hydroxyphenyl-3,5-d2)-4H-1-benzopyran-4-one-3,6,8-d3
CAS Number
263711-74-6
Synonyms
  • [3,6,8,3’,5’-d5]-Apigenin
  • Chamomile-d5
  • Flavone-d5
  • Versulin-d5
Molecular Formula
C15H5D5O5
Formula Weight
275.3
Purity
≥99% deuterated forms (d1-d5); ≤1% d0
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Sparingly Soluble
SMILES
OC1=C([2H])C(O)=C(C(C([2H])=C(C2=CC([2H])=C(O)C([2H])=C2)O3)=O)C3=C1[2H]
InChi Code
InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H/i3D,4D,5D,6D,7D
InChi Key
KZNIFHPLKGYRTM-DKFMXDSJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $160

    Add

    1 mg

    $304

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Apigenin-d5 is an internal standard for the quantificaiton of apigenin (Item No. 10010275) by GC- or LC-MS. Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM to improve renal function in a rat model of glomerulonephritis.1 CK2 inhibition by 20 µM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI-231 cells.2 Apigenin, at 5 µM, is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamada, M., Katsuma, S., Adachi, T., et al. Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis. Proc. Natl. Acad. Sci. USA 102(21), 7736-7741 (2005).

    2. Shen, J., Channavajhala, P., Seldin, D.C., et al. Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IκBα1. J. Immunol. 167(9), 4919-4925 (2001).

    3. Raso, G.M., Meli, R., Di Carlo, G., et al. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci. 68(8), 921-931 (2001).