An internal standard for the quantification of SAHA
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Unlabeled Version(s)
10009929SAHA
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SAHA-d5

Item No. 22107

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1-hydroxy-N8-(phenyl-2,3,4,5,6-d5)-octanediamide
CAS Number
1132749-48-4
Synonyms
  • Suberoylanilide Hydroxamic Acid-d5
  • Vorinostat-d5
Molecular Formula
C14H15D5N2O3
Formula Weight
269.4
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: slightly solubleDMSO: slightly soluble
SMILES
O=C(CCCCCCC(NO)=O)NC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H]
InChi Code
InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)/i3D,4D,5D,8D,9D
InChi Key
WAEXFXRVDQXREF-YQYLVRRTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $169

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    1 mg

    $319

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    Product Description

    SAHA-d5 contains five deuterium atoms at the 2, 3, 4, 5, and 6 positions. It is intended for use as an internal standard for the quantification of SAHA (suberoylanilide hydroxamic acid; Item No. 10009929) by GC- or LC-MS. SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Marks, P.A., and Breslow, R. Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug. Nat. Biotechnol. 25(1), 84-90 (2007).