A free radical spin trap
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NXY-059

Item No. 22109

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(1,1-dimethylethyl)oxidoimino]methyl]-1,3-benzenedisulfonic acid, disodium salt
CAS Number
168021-79-2
Synonyms
  • CPI-22
  • Disufenton Sodium
Molecular Formula
C11H13NO7S2 • 2Na
Formula Weight
381.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
203, 235, 305 nm
SMILES
[O-]S(C1=C(/C=[N+]([O-])/C(C)(C)C)C=CC(S([O-])(=O)=O)=C1)(=O)=O.[Na+].[Na+][O-]S(C1=C(/C=[N+]([O-])/C(C)(C)C)C=CC(S([O-])(=O)=O)=C1)(=O)=O.[Na+].[Na+]
InChi Code
InChI=1S/C11H15NO7S2.2Na/c1-11(2,3)12(13)7-8-4-5-9(20(14,15)16)6-10(8)21(17,18)19;;/h4-7H,1-3H3,(H,14,15,16)(H,17,18,19);;/q;2*+1/p-2/b12-7-;;
InChi Key
XLZOVRYBVCMCGL-BPNVQINPSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $53

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    10 mg

    $98

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    25 mg

    $194

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    50 mg

    $357

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    Product Description

    NXY-059 is a nitrone free radical spin trap with neuroprotective properties.1,2,3 It inhibits transport of tissue plasminogen activator (tPA) from the luminal to the abluminal compartment in an in vitro model of the blood-brain barrier (BBB) under ischemic conditions at a concentration of 250 μM.4 NXY-059 (10 mg/kg per h) decreases infarct volume by 59% in a rat model of transient ischemia induced by occlusion of the middle cerebral artery (MCA).2 It decreases functional disability in the hemiparetic arm of marmosets in the Hill-and-Valley staircase, two-tube choice, and six-tube search tests following MCA occlusion-induced ischemia when administered at a dose of 16 mg/kg per hour.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maples, K.R., Ma, F., and Zhang, Y.-K. Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059. Free Radic Res. 34(4), 417-426 (2001).

    2. Sydserff, S.G., Borelli, A.R., Green, A.R., et al. Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window. Br. J. Pharmacol. 135(1), 103-112 (2002).

    3. Marshall, J.W.B., Duffin, K.J., Green, R., et al. NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Stroke 32(1), 190-198 (2001).

    4. Culot, M., Mysiorek, C., Renftel, M., et al. Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: An in vitro study. Brain Res. 1294, 144-152 (2009).