An internal standard for the quantification of daspone
Related Products
Unlabeled Version(s)
23743Dapsone
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Dapsone-d8

Item No. 22113

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4'-sulfonylbis-benzen-2,3,5,6-d4-amine
CAS Number
557794-38-4
Molecular Formula
C12H4D8N2O2S
Formula Weight
256.3
Purity
≥99% deuterated forms (d1-d8)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
NC1=C([2H])C([2H])=C(S(C2=C([2H])C([2H])=C(N)C([2H])=C2[2H])(=O)=O)C([2H])=C1[2H]
InChi Code
InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2/i1D,2D,3D,4D,5D,6D,7D,8D
InChi Key
MQJKPEGWNLWLTK-PGRXLJNUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $173

    Add

    1 mg

    $327

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Dapsone-d8 is intended for use as an internal standard for the quantification of dapsone (Item No. 23743) by GC- or LC-MS. Dapsone is an anti-inflammatory, antimalarial, and antibacterial compound.1 In vivo, dapsone (34 μg/animal per day) reduces epidermal hyperproliferation and epithelial thickness in the esophagus in a mouse model of proliferative dermatitis.2 It reduces lipid peroxidation, myeloperoxidase activity, and cellular apoptosis in the striatum of rats following ischemia and reperfusion injury.3 Dapsone reduces growth of M. leprae in the footpad of mice (MIC = 0.01-0.03 μg/ml in sera) and induces clearance of P. knowlesi infections in macaques.4,5 It also reduces the number of P. gallinaceum sporozoites in a mosquito population allowed to feed on dapsone-treated chicks.5 Formulations containing dapsone have been used in the treatment of malaria, acne, dermatitis, and leprosy.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bonde, S.L., Bhadane, R.P., Gaikwad, A., et al. Simultaneous determination of dapsone and its major metabolite N-acetyl dapsone by LC-MS/MS method. Int. J. Pharm. Pharm. Sci. 5(Suppl 3), 441-446 (2013).

    2. Gijbels, M.J., Elliott, G.R., HogenEsch, H., et al. Therapeutic interventions in mice with chronic proliferative dermatitis (cpdm/cpdm). Exp. Dermatol. 9(5), 351-358 (2000).

    3. Diaz-Ruiz, A., Zavala, C., Montes, S., et al. Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats. J. Neurosci. Res. 86(15), 3410-3419 (2008).

    4. Holmes, I.B., and Hilson, G.R. The effect of rifampicin and dapsone on experimental Mycobacterium leprae infections: Minimum inhibitory concentrations and bactericidal action. J. Med. Microbiol. 5(2), 251-261 (1972).

    5. Ramakrishnan, S.P., Basu, P.C., Singh, H., et al. Studies on the toxicity and action of diaminodiphenyl-sulfone (DDS) in avian and simian malaria. Bull. World Health Organ. 27(2), 213-221 (1962).