A metabolite of mosapride
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Parent Compound(s)
30048Mosapride (citrate)
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Des-4-fluorobenzyl Mosapride

Item No. 22157

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-5-chloro-2-ethoxy-N-(2-morpholinylmethyl)-benzamide
CAS Number
152013-26-8
Synonyms
  • Des-p-fluorobenzyl Mosapride
Molecular Formula
C14H20ClN3O3
Formula Weight
313.8
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleMethanol: slightly, heated
SMILES
O=C(C1=CC(Cl)=C(N)C=C1OCC)NCC2OCCNC2
InChi Code
InChI=1S/C14H20ClN3O3/c1-2-20-13-6-12(16)11(15)5-10(13)14(19)18-8-9-7-17-3-4-21-9/h5-6,9,17H,2-4,7-8,16H2,1H3,(H,18,19)
InChi Key
HQOQHUQAQLNFOP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    2.5 mg

    $280

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    Product Description

    Des-4-fluorobenzyl Mosapride is the primary metabolite of mosapride. Mosapride is a gastroprokinetic agent that enhances upper GI motility by activating serotonin receptor 4 (5-HT4; EC50 = 74.2 nM, in guinea pig ileal longitudinal muscle myenteric plexus).1,2 Mosapride increases canine, equine, and guinea pig colonic motility in vivo.3,4 Formulations containing mosapride are used in human and veterinary medicine to prevent post-surgical- and Parkinson's-induced constipation.4,5.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mine, Y., Yoshikawa, T., Oku, S., et al. Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro. J. Pharmacol. Exp. Ther. 283(3), 1000-1008 (1997).

    2. Yoshida, N., and Ito, T. Mosapride citrate (AS-4370), a new gastroproltinetic agent, is a partial 5-HT4 receptor agonist in the gut. Neurogastroenterol. Motil. 6(3):, 197-204 (1994).

    3. Yoshida, N., Ito, T., Karasawa, T., et al. AS-4370, a new gastrokinetic agent, enhances upper gastrointestinal motor activity in conscious dogs. J. Pharmacol. Exp. Ther. 257(2):, 781-787 (1991).

    4. Okamura, K., Sasaki, N., Yamada, M., et al. Effects of mosapride citrate, metoclopramide hydrochloride, lidocaine hydrochloride, and cisapride citrate on equine gastric emptying, small intestinal and caecal motility. Res. Vet. Sci. 86(2):, 302-308 (2009).

    5. Liu, Z., Sakakibara, R., Odaka, T., et al. Mosapride citrate, a novel 5-HT4 agonist and partial 5-HT3 antagonist, ameliorates constipation in parkinsonian patients. Mov. Disord. 20(6):, 680-686 (2005).