An inhibitor of Rab geranylgeranyl transferase and P. falciparum FAS II enzymes
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Psoromic Acid

Item No. 22168

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-6-carboxylic acid
CAS Number
7299-11-8
Synonyms
  • NSC 92186
  • Parellic Acid
Molecular Formula
C18H14O8
Formula Weight
358.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: Soluble
SMILES
CC1=C(OC)C=C(C(O)=O)C(OC2=C3C(C)=CC(O)=C2C=O)=C1OC3=O
InChi Code
InChI=1S/C18H14O8/c1-7-4-11(20)10(6-19)15-13(7)18(23)26-14-8(2)12(24-3)5-9(17(21)22)16(14)25-15/h4-6,20H,1-3H3,(H,21,22)
InChi Key
FUCWJKJZOHOLEO-UHFFFAOYSA-N
Origin
Fungus/Usnea sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $160

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    2.5 mg

    $599

    Add
    Cayman Chemical
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    Product Description

    Psoromic acid is an inhibitor of Rab geranylgeranyl transferase (IC50 = 1.3 µM) and P. falciparum fatty acid synthesis (FAS) II. It shows cytotoxic effects on primary rat cerebral cortex and human cancer U87MG cell lines in vitro (IC50s = 79.40 and 56.22 mg/L, respectively). It also is cytotoxic against human KB cancer cells (IC50 = 31.6 µM). It shows moderate activity against liver stage P. beghei (IC50 = 31.6 µM) and drug-resistant blood stage P. falciparum (IC50 = 29.2 µM). The maximum tolerated dose in zebrafish larvae is 15.5 µM.

    WARNING This product is not for human or veterinary use.