A polypeptide antibiotic mixture
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Tyrothricin

Item No. 22177

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
1404-88-2
Molecular Formula
C66H87N13O13 (for Tyrocidine A)
Purity
≥95% composite purity (based on 80% tyrocidine and 20% gramicidin complexes)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
O=C(N1CCC[C@]1(C(N[C@@H](CC2=CC=CC=C2)C(N[C@]([H])(CC3=CC=CC=C3)C(N[C@@H](CC(N)=O)C(N[C@H]4CCC(N)=O)=O)=O)=O)=O)[H])[C@@]([H])(CC5=CC=CC=C5)NC([C@H](CC(C)C)NC([C@]([H])(CCCN)NC([C@H](C(C)C)NC([C@H](CC6=CC=C(C=C6)O)NC4=O)=O)=O)=O)=O.O=C(N[C@@H](C)C(N[C@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](C(N[C@H](C(N[C@H](C(C)C)C(N[C@H](C(N[C@H](CC(C)C)C(N[C@H](C(N[C@H](CC(C)C)C(N[C@@H](CC7=CNC8=C7C=CC=C8)C(N[C@H](CC(C)C)C(N[C@@H](CC9=CNC%10=C9C=CC=C%10)C(NCCO)=O)=O)=O)=O)=O)CC%11=CNC%12=C%11C=CC=C%12)=O)=O)CC%13=CNC%14=C%13C=CC=C%14)=O)=O)C(C)C)=O)C(C)C)=O)=O)=O)CNC([C@H](C(C)C)NC([H])=O)=O
InChi Code
InChI=1S/C99H140N20O17.C66H87N13O13/c1-51(2)37-73(109-86(123)59(17)107-81(122)49-105-96(133)82(55(9)10)106-50-121)89(126)108-60(18)87(124)117-84(57(13)14)98(135)119-85(58(15)16)99(136)118-83(56(11)12)97(134)116-80(44-64-48-104-72-34-26-22-30-68(64)72)95(132)112-76(40-54(7)8)92(129)115-79(43-63-47-103-71-33-25-21-29-67(63)71)94(131)111-75(39-53(5)6)91(128)114-78(42-62-46-102-70-32-24-20-28-66(62)70)93(130)110-74(38-52(3)4)90(127)113-77(88(125)100-35-36-120)41-61-45-101-69-31-23-19-27-65(61)69;1-38(2)32-47-59(85)77-52(36-42-20-12-7-13-21-42)66(92)79-31-15-23-53(79)64(90)76-49(34-41-18-10-6-11-19-41)61(87)74-48(33-40-16-8-5-9-17-40)60(86)75-51(37-55(69)82)62(88)70-46(28-29-54(68)81)58(84)73-50(35-43-24-26-44(80)27-25-43)63(89)78-56(39(3)4)65(91)71-45(22-14-30-67)57(83)72-47/h19-34,45-48,50-60,73-80,82-85,101-104,120H,35-44,49H2,1-18H3,(H,100,125)(H,105,133)(H,106,121)(H,107,122)(H,108,126)(H,109,123)(H,110,130)(H,111,131)(H,112,132)(H,113,127)(H,114,128)(H,115,129)(H,116,134)(H,117,124)(H,118,136)(H,119,135);5-13,16-21,24-27,38-39,45-53,56,80H,14-15,22-23,28-37,67H2,1-4H3,(H2,68,81)(H2,69,82)(H,70,88)(H,71,91)(H,72,83)(H,73,84)(H,74,87)(H,75,86)(H,76,90)(H,77,85)(H,78,89)/t59-,60-,73+,74+,75+,76+,77-,78-,79-,80-,82-,83+,84+,85-;45-,46-,47-,48+,49-,50-,51-,52+,53-,56-/m00/s1
InChi Key
ATKYBFJRKHIKCW-LATDSDEZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $37

    Add

    5 mg

    $99

    Add

    10 mg

    $145

    Add

    25 mg

    $225

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Tyrothricin is a polypeptide antibiotic mixture produced by B. brevis.1,2 Tyrothricin is a mixture of tyrocidine and gramicidin that has rapid in vitro bactericidal activity against T. microdentium, T. macrodentium, T. vincentii, T. buccalis, T. mucosum, T. vaginalis, T. cruzi, and L. tropica.2 Preclinical studies demonstrate that intravenous use of tyrothricin leads to hemolysis-induced lethality (LD50s = 0.4 and 0.3 mg/kg, in dogs and mice, respectively) and damages liver, kidney, and olfactory tissues. Formulations containing tyrothricin are used topically to treat bacterial skin infections.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dubos, R.J., and Hotchkiss, R.D. The production of bactericidal substances by aerobic sporulating bacilli. J. Exp. Med. 73(5), 629-640 (1941).

    2. Lask, S.A. Tyrothricin as an antibiotic. Arch. Surg. 56(4), 475-483 (1948).