An NMDAR partial agonist
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D-Cycloserine

Item No. 22194

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4R-amino-3-isoxazolidinone
CAS Number
68-41-7
Synonyms
  • (+)-Cycloserine
  • α-Cycloserine
  • (R)-Cycloserine
  • NSC 76029
  • NSC 154851
Molecular Formula
C3H6N2O2
Formula Weight
102.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
225 nm
SMILES
O=C1[C@H](N)CON1
InChi Code
InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
InChi Key
DYDCUQKUCUHJBH-UWTATZPHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $44

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    1 g

    $80

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    5 g

    $215

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    Product Description

    D-Cycloserine is an NMDA receptor (NMDAR) partial agonist with antibiotic activity. It selectively binds to the glycine binding site (Ki = 2.33 μM) over the glutamate binding site (Ki = >100 μM).1 D-Cycloserine modulates memory in a T-maze footshock test in CD-1 mice with optimal memory retention at doses of 10-30 mg/kg.2 Administration of D-cycloserine (20-40 mg/kg) improves memory retention in ‘senescence-accelerated’ mice which exhibit impaired learning and memory. D-Cycloserine inhibits L-alanine racemase and D-alanine:D-alanine ligase, enzymes essential to peptidoglycan synthesis and bacterial cell wall formation.3 Formulations containing D-cycloserine have been used as second-line agents to treat drug resistant tuberculosis.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hood, W.F., Compton, R.P., and Monahan, J.B. D-cycloserine: A ligand for the N-methyl-D-aspartate coupled glycine receptor has partial agonist characteristics. Neurosci. Lett. 98(1), 91-95 (1989).

    2. Flood, J.F., Morley, J.E., and Lanthorn, T.H. Effect on memory processing by D-cycloserine, an agonist of the NMDA/glycine receptor. Eur. J. Pharmacol. 221(2-3), 249-254 (1992).

    3. Feng, Z., and Barletta, R.G. Roles of Mycobacterium smegmatis D-alanine:D-alanine ligase and D-alanine racemase in the mechanisms of action of and resistance to the peptidoglycan inhibitor D-cycloserine. Antimicrob. Agents Chemother. 47(1), 283-291 (2003).

    4. Caminero, J.A., Sotqiu, G., Zumla, A., et al. Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis. Lancet Infect. Dis. 10(9), 621-629 (2010).