A positive allosteric modulator of mGluR5
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VU0357121

Item No. 22199

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-butoxy-N-(2,4-difluorophenyl)-benzamide
CAS Number
433967-28-3
Molecular Formula
C17H17F2NO2
Formula Weight
305.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 15 mg/ml
λmax
262 nm
SMILES
FC1=CC(F)=C(NC(C2=CC=C(OCCCC)C=C2)=O)C=C1
InChi Code
InChI=1S/C17H17F2NO2/c1-2-3-10-22-14-7-4-12(5-8-14)17(21)20-16-9-6-13(18)11-15(16)19/h4-9,11H,2-3,10H2,1H3,(H,20,21)
InChi Key
AHCYOTLTLQTPSU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $143

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    25 mg

    $333

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    50 mg

    $589

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    Product Description

    VU0357121 is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) that has an EC50 value of 33 nM for the rat receptor expressed in HEK293 cells in a calcium flux assay.1 It is selective for mGluR5 and does not modulate responses at mGluR2-4 or mGluR6-8 but does inhibit mGluR1.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hammond, A.X., Rodriguez, A.L., Townsend, S.D., et al. Discovery of a novel chemical class of mGlu5 allosteric ligands with distinct modes of pharmacology. ACS Chem. Neurosci. 1(10), 702-716 (2010).