A selective BCRP inhibitor
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KS-176

Item No. 22201

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(2-hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]-benzamide
CAS Number
1253452-78-6
Molecular Formula
C22H19N3O5
Formula Weight
405.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
λmax
260 nm
SMILES
O=C(NC1=C(C(NC2=CC=C(CCO)C=C2)=O)C=CC=C1)C3=CC=C([N+]([O-])=O)C=C3
InChi Code
InChI=1S/C22H19N3O5/c26-14-13-15-5-9-17(10-6-15)23-22(28)19-3-1-2-4-20(19)24-21(27)16-7-11-18(12-8-16)25(29)30/h1-12,26H,13-14H2,(H,23,28)(H,24,27)
InChi Key
LTWQQWSXYYXVGA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $236

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    25 mg

    $544

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    Cayman Chemical
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    Product Description

    KS-176 is a selective inhibitor of breast cancer resistance protein (BRCP; IC50 = 1.39 μM) with no activity against P-glycoprotein (P-gp) or multidrug resistance-associated protein 1 (MRP1).1 It acts as a non-competitive inhibitor whose potency is increased by imatinib binding. KS-176 does not reduce cell viability at concentrations up to 10 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pick, A., Klinkhammer, W., and Wiese, M. Specific inhibitors of the breast cancer resistance protein (BCRP). ChemMedChem 5(9), 1498-1505 (2010).