An anticancer compound
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Product Type

Biochemicals

Research Area

Cancer
Angiogenesis
Cell Death
Apoptosis

TRX-818 (sodium salt)

Item No. 22209

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3-fluorophenyl)-6-methoxy-5-(phosphonooxy)-4(1H)-quinolinone, disodium salt
CAS Number
1256037-62-3
Molecular Formula
C16H11FNO6P • 2Na
Formula Weight
409.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 0.5 mg/ml
λmax
271, 356 nm
SMILES
O=C1C2=C(C=CC(OC)=C2OP([O-])([O-])=O)NC(C3=CC(F)=CC=C3)=C1.[Na+].[Na+]
InChi Code
InChI=1S/C16H13FNO6P.2Na/c1-23-14-6-5-11-15(16(14)24-25(20,21)22)13(19)8-12(18-11)9-3-2-4-10(17)7-9;;/h2-8H,1H3,(H,18,19)(H2,20,21,22);;/q;2*+1/p-2
InChi Key
TWMCXXQLLQDSTN-UHFFFAOYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    TRX-818 is an anticancer compound.1,2 It inhibits vasculogenic mimicry network formation in C8161 and SK-MEL-28 melanoma cells when used at concentrations ranging from less than or equal to 5 to 10 nM. 1 TRX-818 (10 nM) decreases pro-Nodal protein levels and Smad2 phosphorylation in C8161 cells. It reduces tumor volume with a minimum effective dose (MED) value of 50 mg/kg and decreases the number of vasculogenic mimicry channels in tumors when administered at a dose of 100 mg/kg in an HCT116 colon cancer mouse xenograft model. TRX-818 (7.5, 15, and 30 mg/kg) reduces tumor growth in a Hep3B mouse xenograft model in a dose-dependent manner.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chu, Y.-W., and Chien, D.-S. Use of aryl-quinolin derivatives as inhibitors of vasculogenic mimicry. (2016).

    2. Chou, L.-C., Tsai, M.-T., Hsu, M.-H., et al. Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents. J. Med. Chem. 53(22), 8047-8058 (2010).