A synthetic estrogen
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β-Estradiol 17-valerate

Item No. 22221

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(17β)-estra-1,3,5(10)-triene-3,17-diol, 17-pentanoate
CAS Number
979-32-8
Synonyms
  • Estradiol 17β-valerate
  • NSC 17590
Molecular Formula
C23H32O3
Formula Weight
356.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 2 mg/ml
λmax
282 nm
SMILES
C[C@@]12[C@](CC[C@@H]2OC(CCCC)=O)([H])[C@]([C@]3([H])CC1)([H])CCC4=C3C=CC(O)=C4
InChi Code
InChI=1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3/t18-,19-,20+,21+,23+/m1/s1
InChi Key
RSEPBGGWRJCQGY-RBRWEJTLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

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    Product Description

    β-Estradiol 17-valerate is a synthetic estrogen.1,2,3 It increases estrogen receptor β (ERβ), but not ERα, levels in the hippocampus and cortex of ovariectomized rats when administered at a dose of 0.3 mg/day.1 Intradermal administration of β-estradiol 17-valerate (5 µg/animal) induces transient permanent diestrus and decreases litter size in rats.2 β-Estradiol 17-valerate has been used to induce polycystic ovarian syndrome in rats.3 It has been found in wastewater effluent.4 Formulations containing β-estradiol 17-valerate have been used in hormone replacement therapy and in the treatment of menopausal symptoms, as well as in oral contraceptives in combination with dienogest.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jin, M., Jin, F., Zhang, L., et al. Two estrogen replacement therapies differentially regulate expression of estrogen receptors alpha and beta in the hippocampus and cortex of ovariectomized rat. Brain Res. Mol. Brain Res. 142(2), 107-114 (2005).

    2. Seidman, D.S., Itsekson, A., Alesker, M., et al. Estradiol valerate as a possible endocrine reproductive disruptor: Evidence from an in vivo rat model. Fertil. Steril. 91(4 Suppl), 1510-1512 (2009).

    3. Dikmen, A., Ergenolglu, A.M., Yeniel, A.O., et al. Evaluation of glycemic and oxidative/antioxidative status in the estradiol valerate-induced PCOS model of rats. Eur. J. Obstet. Gynecol. Reprod. Biol. 160(1), 55-59 (2012).

    4. Zhou, Y., Zha, J., Xu, Y., et al. Occurrences of six steroid estrogens from different effluents in Beijing, China. Environ. Monit. Assess. 184(3), 1719-1729 (2012).