A phosphodiesterase inhibitor and adenosine receptor antagonist
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21068Paraxanthine 21745Theobromine
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Aminophylline

Item No. 22235

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione 1,2-ethanediamine (2:1)
CAS Number
317-34-0
Molecular Formula
C7H8N4O2 • 1/2C2H8N2
Formula Weight
180.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlEthanol: 0.2 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
272 nm
SMILES
CN(C(N1C)=O)C2=C(N=CN2)C1=O.CN(C(N3C)=O)C4=C(N=CN4)C3=O.NCCN
InChi Code
InChI=1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2
InChi Key
FQPFAHBPWDRTLU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

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    Product Description

    Aminophylline is a competitive and non-selective phosphodiesterase inhibitor (IC50 = 120 µM) and adenosine receptor antagonist.1,2 It is a complex of theophylline and ethylenediamine that has in vivo bronchodilator and vasodilator effects.1,3 Aminophylline suppresses maternal separation- and acetic acid administration-induced visceral hypersensitivity to colorectal distension in a rat model of irritable bowel syndrome with diarrhea (IBS-D).4 Aminophylline also provides renoprotection against murine renal ischemia-reperfusion injury.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ruthorford, J.D., Vatner, S.F., and Braunwald, E. Effects and mechanism of action of aminophylline on cardiac function and regional blood flow distribution in conscious dogs. Circulation 63(2), 378-387 (1981).

    2. Davari., A.S., Abnous, K., Mehri, S., et al. Synthesis and biological evaluation of novel pyridine derivatives as potential anticancer agents and phosphodiesterase-3 inhibitors. Bioorg. Chem. 57, 83-89 (2014).

    3. Tai, E.S., and Read, J. Response of blood gas tensions to aminophylline and isoprenaline in patients with asthma. Thorax 22(6), 543-549 (1967).

    4. Asano, T., Tanaka, K.-i., Tada, A., et al. Aminophylline suppresses stressinduced visceral hypersensitivity and defecation in irritable bowel syndrome. Sci. Rep. 7:40214, (2017).

    5. Seo, K., Choi, J.W., Kim, D.-W., et al. Aminophylline effect on renal ischemia-reperfusion injury in mice. Transplant Proc. 49(2), 358-365 (2017).