A potent KOR agonist
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Salvinorin A Carbamate

Item No. 22245

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,4aR,6aR,7R,9S,10aS,10bR)-9-[(aminocarbonyl)oxy]-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid, methyl ester
CAS Number
858345-57-0
Synonyms
  • Divinorin A Carbamate
  • Sal A Carbamate
Molecular Formula
C22H27NO8
Formula Weight
433.5
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: 1 mg/mlDMF: 1 mg/mlDMSO: 2 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
[H][C@@]12CC[C@@]([C@@]3([H])[C@@]1(C)C[C@@H](C4=COC=C4)OC2=O)(C)[C@H](C(OC)=O)C[C@H](OC(N)=O)C3=O
InChi Code
InChI=1S/C22H27NO8/c1-21-6-4-12-19(26)30-15(11-5-7-29-10-11)9-22(12,2)17(21)16(24)14(31-20(23)27)8-13(21)18(25)28-3/h5,7,10,12-15,17H,4,6,8-9H2,1-3H3,(H2,23,27)/t12-,13-,14-,15-,17-,21-,22-/m0/s1
InChi Key
FHTGZEVOZWRYEL-XOKLNVNFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $107

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    1 mg

    $203

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    5 mg

    $845

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    Product Description

    Salvinorin A carbamate is a potent κ-opioid receptor (KOR) full agonist that is almost as potent as salvinorin A (Item No. 11487) with EC50 values of 6.2 and 4.5 nM, respectively, for activation of the human KOR to enhance binding of [35S]GTPγS.1 The addition of a carbamate group to salvinorin A increases biological stability by decreasing deacetylation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Béguin, C., Richards, M.R., Wang, Y., et al. Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2). Bioorg. Med. Chem. Lett. 15(11), 2761-2765 (2005).