A selective norepinephrine reuptake inhibitor
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Atomoxetine (hydrochloride)

Item No. 22248

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-γR-(2-methylphenoxy)-benzenepropanamine, monohydrochloride
CAS Number
82248-59-7
Synonyms
  • LY139603
Molecular Formula
C17H21NO • HCl
Formula Weight
291.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
279 nm
SMILES
CNCC[C@H](C1=CC=CC=C1)OC2=CC=CC=C2C.Cl
InChi Code
InChI=1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
InChi Key
LUCXVPAZUDVVBT-UNTBIKODSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $81

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    10 mg

    $145

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    25 mg

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    50 mg

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    Product Description

    Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki values of 5, 77, and 1,451 nM for norepinephrine, serotonin, and dopamine transporters, respectively.1 It is selective over the choline, GABA, and adenosine transporters, and a number of neurotransmitter receptors, ion channels, second messengers, and brain/gut peptides. In the rat prefrontal cortex (PFC), it increases extracellular norepinephrine and dopamine by 3-fold and increases Fos expression. Atomoxetine (0.1, 0.5, and 1 mg/kg) reduces premature responding, a measure of impulsivity, by rats in the 5-choice serial reaction time test (5CSRTT) in a dose-dependent manner.2 It also has neuroprotective effects when administered prior to ischemic damage in a gerbil model of transient cerebral ischemia.3 Formulations containing atomoxetine have been used in the treatment of attention-deficit hyperactivity disorder (ADHD) in children, adolescents, and adults.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bymaster, F.P., Katner, J.S., Nelson, D.L., et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: A potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27(5), 699-711 (2002).

    2. Blondeau, C., and Dellu-Hagedorn, F. Dimensional analysis of ADHD subtypes in rats. Biol. Psychiatry 61(12), 1340-1350 (2007).

    3. Park, J.H., Shin, B.N., Chen, B.H., et al. Neuroprotection and reduced gliosis by atomoxetine pretreatment in a gerbil model of transient cerebral ischemia. J. Neurol. Sci. 359(1-2), 373-380 (2015).