An inhibitor of cancer cell stemness
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Napabucasin

Item No. 22255

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-acetyl-naphtho[2,3-b]furan-4,9-dione
CAS Number
83280-65-3
Synonyms
  • BBI 608
Molecular Formula
C14H8O4
Formula Weight
240.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 0.5 mg/ml
λmax
205, 253, 339 nm
SMILES
O=C(C(OC(C(C)=O)=C1)=C1C2=O)C3=C2C=CC=C3
InChi Code
InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H,1H3
InChi Key
DPHUWDIXHNQOSY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $128

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    25 mg

    $295

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    50 mg

    $553

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    Cayman Chemical
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    Product Description

    Napabucasin is an inhibitor of cancer cell stemness.1 It reduces growth in a panel of cancer cells enriched for high stemness (IC50s = 0.291-1.249 μM) and decreases protein and gene expression of various self-renewal and pro-survival markers including Nanog, Smo, Axl, Atm, and Bmi-1 in a concentration-dependent manner in FaDu head and neck squamous cell carcinoma (HNSCC) cells. In vivo, napabucasin (20 mg/kg per day) inhibits tumor growth in a PaCa-2 mouse xenograft model and prevents tumor regrowth after cessation of treatment. It blocks formation of spleen and liver metastases in an HT29 intrasplenic nude mouse model system (ISMS) model. Napabucasin (40 mg/kg, i.p.) also reduces tumor volume in PC3 and 22RV1 prostate cancer mouse xenograft models.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, Y., Rogoff, H.A., Keates, S.G., et al. Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc. Natl. Acad. Sci. USA 112(6), 1839-1844 (2015).

    2. Zhang, Y., Jin, Z., Zhou, H., et al. Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin. Cancer Med. 5(6), 1251-1258 (2016).