An antibiotic and LpxC inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

CHIR090

Item No. 22256

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[2-[4-(4-morpholinylmethyl)phenyl]ethynyl]-benzamide
CAS Number
728865-23-4
Molecular Formula
C24H27N3O5
Formula Weight
437.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2.5 mg/ml
λmax
299 nm
SMILES
O=C(N[C@H](C(NO)=O)[C@H](O)C)C1=CC=C(C#CC2=CC=C(CN3CCOCC3)C=C2)C=C1
InChi Code
InChI=1S/C24H27N3O5/c1-17(28)22(24(30)26-31)25-23(29)21-10-8-19(9-11-21)3-2-18-4-6-20(7-5-18)16-27-12-14-32-15-13-27/h4-11,17,22,28,31H,12-16H2,1H3,(H,25,29)(H,26,30)/t17-,22+/m1/s1
InChi Key
FQYBTYFKOHPWQT-VGSWGCGISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $63

    Add

    5 mg

    $183

    Add

    10 mg

    $303

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    CHIR090 is an antibiotic that inhibits LpxC, a deacetylase involved in the biosynthesis of LPS lipid A, with Ki values of 1-1.7 nM in A. aeolicus.1 It is active against Gram-negative bacteria with MIC values of 0.05, 0.78, and 0.10-6.25 mg/ml for E. coli, P. aeruginosa, and various B. multivorans (II) strains, respectively.2,3 It is comparable in strength to ciprofloxacin (Item No. 14286) in disc assays.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McClerren, A.L., Endsley, S., Bowman, J.L., et al. A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin. Biochemistry 44(50), 16574-16583 (2005).

    2. Barb, A.W., McClerren, A.L., Snehelatha, K., et al. Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli. Biochemistry 46(12), 3793-3802 (2007).

    3. Bodewits, K., Raetz, C.R., Govan, J.R., et al. Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. Antimicrob. Agents Chemother. 54(8), 3531-3533 (2010).