Aloperine

Aloperine is an alkaloid found in the roots of S. flavescens with diverse biological activities including antiviral, anticancer, antioxidant, and anti-inflammatory actions.^1,2,3,4 It inhibits HIV-1 replication and envelope-mediated cell-cell fusion (EC₅₀s = 1.75 and 1.2 μM, respectively) at concentrations well below the cytotoxic concentration (CC₅₀) of >86.5 μM in vitro.¹ Aloperine inhibits the growth of HL-60, U937, and K562 leukemia cell lines with IC₅₀ values of 40, 270, and 360 μM, respectively.² Administration of aloperine, at a dose of 60 mg/kg, reduces NOX2, NOX4, superoxide dismutase, and glutathione peroxidase expression in lungs in a rat model of pulmonary hypertension.³ Topical administration of aloperine reduces ear swelling, ear erythema, and production of inflammatory cytokines TNF-α, IL-1β, and IL-6 in a mouse model of allergic contact dermatitis.⁴

WARNING This product is not for human or veterinary use.

1. Dang, Z., Zhu, L., Lai, W., et al. Aloperine and its derivatives as a new class of HIV-1 entry inhibitors. ACS Med. Chem. Lett. 7(3), 240-244 (2016).

2. Lin, Z., Huang, C.-F., Liu, X.-S., et al. In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait. Basic Clin. Pharmacol. Toxicol. 108(5), 304-309 (2011).

3. Wu, F., Hao, Y., Yang, J., et al. Protective effects of aloperine on monocrotaline-induced pulmonary hypertension in rats. Biomed Pharmacother. 89, 632-641 (2017).

4. Yuan, X.Y., Liu, W., Zhang, P., et al. Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice. Eur. J. Pharmacol. 629(1-3), 147-152 (2010).