An internal standard for the quantification of ethyl-β-D-glucuronide
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Unlabeled Version(s)
22271Ethyl-β-D-Glucuronide
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Ethyl-β-D-Glucuronide-d5

Item No. 22273

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
β-D-glucopyranosiduronic acid, ethyl-d5
CAS Number
1135070-98-2
Synonyms
  • Ethyl-β-D-Glucopyranosiduronic Acid-d5
  • Ethyl-β-D-Glucosiduronic Acid-d5
Molecular Formula
C8H9D5O7
Formula Weight
227.2
Purity
≥99% deuterated forms (d1-d5)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O[C@@H]1[C@@H](O)[C@H](OC([2H])([2H])C([2H])([2H])[2H])O[C@H](C(O)=O)[C@H]1O
InChi Code
InChI=1S/C8H14O7/c1-2-14-8-5(11)3(9)4(10)6(15-8)7(12)13/h3-6,8-11H,2H2,1H3,(H,12,13)/t3-,4-,5+,6-,8+/m0/s1/i1D3,2D2
InChi Key
IWJBVMJWSPZNJH-XTJTXKPGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $116

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    1 mg

    $220

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    5 mg

    $809

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    10 mg

    $1,155

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    Product Description

    Ethyl-β-D-Glucuronide-d5 is intended for use as an internal standard for the quantification of ethyl-β-D-glucuronide (Item No. 22271) by GC- or LC-MS. Ethyl-β-D-glucuronide is a minor metabolite of ethanol.1,2 It is primarily formed from ethanol by UDP glucuronosyltransferases (UGTs), but it can also be formed via β-glucuronidase cleavage and transfer of the glucuronide moiety in various non-ethanol-containing β-glucuronides to ethanol.3 Hair levels of ethyl-β-D-glucuronide are positively correlated with alcohol consumption in patients with alcohol dependence syndrome.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schmitt, G., Aderjan, R., Keller, T., et al. Ethyl glucuronide: An unusual ethanol metabolite in humans. Synthesis, analytical data, and determination in serum and urine. J. Anal. Toxicol. 19(2), 91-94 (1995).

    2. Beck, O., Stephanson, N., Bötthcer, M., et al. Biomarkers to disclose recent intake of alcohol: Potential of 5-hydroxytryptophol glucuronide testing using new direct UPLC-tandem MS and ELISA methods. Alcohol Alcohol. 42(4), 321-325 (2007).

    3. Müller , A., Aboutara, N., Jungen, H., et al. Beta-glucuronidase activity: Another source of ethyl glucuronide. J. Anal. Toxicol. 47(2), 114-120 (2023).

    4. Ghosh, S., Jain, R., Rao, R., et al. Does ethyl glucuronide in hair correlate with alcohol consumption? A comparative study with other traditional biomarkers among individuals with alcohol dependence syndrome. Alcohol 105, 55-60 (2023).