A synthetic GnRH receptor agonist
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Leuprorelin (acetate)

Item No. 22275

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-D-leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (swine), acetate
CAS Number
88793-81-1
Molecular Formula
C59H84N16O12 • XC2H4O2
Formula Weight
1209.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 0.25 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
222, 276 nm
SMILES
O=C([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC3=CNC=N3)NC([C@@H]4CCC(N4)=O)=O)=O)N[C@H](C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](C(N[C@H](C(N[C@H](C(N6CCC[C@H]6C(NCC)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C)=O)=O)CO.OC(C)=O
InChi Code
InChI=1S/C59H84N16O12.C2H4O2/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40;1-2(3)4/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64);1H3,(H,3,4)/t40-,41-,42-,43+,44-,45-,46-,47-,48-;/m0./s1
InChi Key
RGLRXNKKBLIBQS-XNHQSDQCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $186

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    25 mg

    $420

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    Cayman Chemical
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    Product Description

    Leuprorelin is a synthetic gonadotropin-releasing hormone (GnRH) receptor agonist.1 It is a long-acting agent that, after an initial increase in sex hormone levels, decreases the level of circulating gonadotropins and sex hormones. Formulations containing leuprorelin have been used in the treatment of hormone-dependent prostate and breast cancers, endometriosis, and precocious puberty.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Plosker, G.L., and Brogden, R.N. Leuprorelin. A review of its pharmacology and therapeutic use in prostatic cancer, endometriosis and other sex hormone-related disorders. Drugs. 48(6), 930-967 (1994).

    2. Gravel, P., Samland, D., Löffler, M., et al. Two innovative pharmaceutical forms of leuprorelin: results from 818 patients with advanced prostate cancer. Adv. Ther. 30(3), 271-285 (2013).