An uncompetitive inhibitor of alkaline phosphatases
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

L-Homoarginine (hydrochloride)

Item No. 22285

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N6-(aminoiminomethyl)-L-lysine, monohydrochloride
CAS Number
1483-01-8
Synonyms
  • NSC 145416
Molecular Formula
C7H16N4O2 • HCl
Formula Weight
224.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
NC(NCCCC[C@H](N)C(O)=O)=N.Cl
InChi Code
InChI=1S/C7H16N4O2.ClH/c8-5(6(12)13)3-1-2-4-11-7(9)10;/h5H,1-4,8H2,(H,12,13)(H4,9,10,11);1H/t5-;/m0./s1
InChi Key
YMKBVNVCKUYUDM-JEDNCBNOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 g

    $49

    Add

    5 g

    $202

    Add

    10 g

    $329

    Add

    25 g

    $690

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    L-Homoarginine is an uncompetitive and organ-specific inhibitor of alkaline phosphatases.1 This non-essential amino acid inhibits human bone and liver alkaline phosphatases but has no effect on placental or intestinal isoenzymes. In vitro, L-homoarginine inhibits [3H]thymidine uptake by mouse myeloma MOPC 104E cells and inhibits proliferation of C3H/He mouse osteosarcoma cells.2 Pre-treatment with L-homoarginine delays in vivo tumor growth in a murine C3H/He osteosarcoma model. It also inhibits high-protein diet-induced pancreatic growth and enzyme secretion in bile-pancreatic juice-diverted rats, a model for the induction of pancreatic enzyme secretion with hypercholecystokininemia.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, C.W., and Fishman, W.H. L-Homoarginine. An organ-specific, uncompetitive inhibitor of human liver and bone alkaline phosphohydrolases. The Journal of Biological Chemisty 247(10), 3082-3087 (1972).

    2. Kikuchi, Y., Takagi, M., Parmley, R.T., et al. Inhibitory effect of L-homoarginine on murine osteosarcoma cell proliferation. Cancer Res. 42(3), 1072-1077 (1982).

    3. Hira, T., Ohyama, S., and Hara, H. L-homoarginine suppresses exocrine pancreas in rats. Amino Acids 24(4), 389-396 (2003).