A potent inhibitor of pancreatic elastase
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Elastatinal

Item No. 22288

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxyethyl]-L-glutamamide
CAS Number
51798-45-9
Molecular Formula
C21H36N8O7
Formula Weight
512.6
Purity
≥85%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
NC1=NCC[C@]([C@H](NC(N[C@H](C(O)=O)CC(C)C)=O)C(N[C@H](C(N[C@@H](C)C=O)=O)CCC(N)=O)=O)([H])N1
InChi Code
InChI=1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)/t11-,12-,13-,14-,16-/m0/s1
InChi Key
IJWCGVPEDDQUDE-YGJAXBLXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Elastatinal is a potent inhibitor of pancreatic elastase (Ki = 240 nM) that is produced by various species of Actinomycetes.1 It more strongly inhibits pancreatic elastase versus the leukocyte-derived enzyme.2,3 Elastatinal reduces electrophoretic mobilities of 2A proteinases from poliovirus and human rhinovirus 14 in a dose-dependent manner, indicating substrate recognition by 2A proteinases is similar to that of pancreatic elastases.4 It can also inhibit elastase-like protease collagenolytic protease from C. maenas digestive glands.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Umezawa, H. Structures and activities of protease inhibitors of microbial origin. Methods Enzymol. 45, 678-695 (1976).

    2. Feinstein, G., Malemud, C.J., and Janoff, A. The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin. Biochim. Biophys. Acta 429(3), 925-932 (1976).

    3. Okumura, Y., Ogawa, K., and Uchiya, K. Characterization and primary structure of elastase inhibitor, AFLEI, from Aspergillus flavus. Nishon Ishinkin Gakkai Zasshi 48(1), 13-18 (2007).

    4. Molla, A., Hellen, C.U.T., and Wimmer, E. Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors. J. Virol. 67(8), 4688-4695 (1993).

    5. Roy, P., Colas, B., and Durand, P. Purification, kinetical and molecular characterizations of a serine collagenolytic protease from greenshore crag (Carcinus maenas) digestive gland. Comp. Biochem. Physiol. Biochem. Mol. Biol. 115(1), 87-95 (1996).