A selective κ1-opioid receptor partial agonist
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Salvinorin A Propionate

Item No. 22290

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-9-(1-oxopropoxy)-2H-naphtho[2,1-c]pyran-7-carboxylic acid, methyl ester
CAS Number
689295-71-4
Synonyms
  • Divinorin A Propionate
  • Sal A Propionate
  • Sal-2-propionate
  • Salvinorinyl-2-propionate
Molecular Formula
C24H30O8
Formula Weight
446.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: 1 mg/mlDMF: 2 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 1 mg/ml
λmax
211, 258, 273 nm
SMILES
[H][C@@]12CC[C@@]([C@@]3([H])[C@@]1(C)C[C@@H](C4=COC=C4)OC2=O)(C)[C@H](C(OC)=O)C[C@H](OC(CC)=O)C3=O
InChi Code
InChI=1S/C24H30O8/c1-5-18(25)31-16-10-15(21(27)29-4)23(2)8-6-14-22(28)32-17(13-7-9-30-12-13)11-24(14,3)20(23)19(16)26/h7,9,12,14-17,20H,5-6,8,10-11H2,1-4H3/t14-,15-,16-,17-,20-,23-,24-/m0/s1
InChi Key
UPFVFWZGNRKYFG-ZWLNRFIDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $213

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    10 mg

    $376

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    Product Description

    Salvinorin A propionate is a selective partial agonist at κ1-opioid receptors (KOR) with a Ki value of 32.6 nM.1 It inhibits adenylate cyclase (EC50 = 4.7 nM) in HEK293 cells transfected with human KOR.2 It is selective for KORs over µ, δ, and ORL-1 opioid receptors and has no effect at serotonin, dopamine, muscarinic, or adrenergic receptors. In mice, salvinorin A propionate (13 µg, i.c.v.) reduces nociceptive responses in a radiant heat tail-flick assay, though not as potently as salvinorin A (Item No. 11487).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ansonoff, M.A., Zhang, J., Czyzk, T., et al. Antinociceptive and hypothermic effects of salvinorin A are abolished in a novel strain of κ-opioid receptor-1 knockout mice. J. Pharmacol. Exp. Ther. 318(2), 641-648 (2006).

    2. Chavkin, C., Sud, S., Jin, W., et al. Salvinorin A, an active component of the hallucinogenic sage Salvia divinorum is a highly efficacious κ-opioid receptor agonist: Structural and functional considerations. J. Pharmacol. Exp. Ther. 308(3), 1197-1203 (2004).