A phytosterol
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Brassicasterol

Item No. 22296

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
ergosta-5,22E-dien-3β-ol
CAS Number
474-67-9
Molecular Formula
C28H46O
Formula Weight
398.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 0.1 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
SMILES
CC(C)[C@@H](C)/C=C/[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C28H46O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-9,18-20,22-26,29H,10-17H2,1-6H3/b8-7+/t19-,20+,22-,23-,24+,25-,26-,27-,28+/m0/s1
InChi Key
OILXMJHPFNGGTO-ZAUYPBDWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Brassicasterol is a phytosterol found in canola and rapeseed oils, marine algae, and shellfish.1 It inhibits recombinant sterol Δ24-reductase with a Ki value of 42.7 μM in vitro. Brassicasterol increases accumulation of desmosterol, a cholesterol precursor and substrate of sterol Δ24-reductase, and inhibits cholesterol formation in HL-60 cells in a dose-dependent manner. It also inhibits the hemolytic activity of pneumolysin from S. pneumoniae without affecting bacterial growth at concentrations up to 1,000 μg/ml.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fernández, C., Suárez, Y., Ferruelo, A.J., et al. Inhibition of cholesterol biosynthesis by Δ22-unsaturated phytosterols via competitive inhibition of sterol Δ24-reductase in mammalian cells. Biochem. J. 366(Pt 1), 109-119 (2002).

    2. Li, H., Zhao, X., Deng, X., et al. Insights into structure and activity of natural compound inhibitors of pneumolysin. Sci. Rep. 7:42015, (2017).