A KCa1.1/BK channel activator
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BMS 191011

Item No. 22299

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one
CAS Number
202821-81-6
Molecular Formula
C16H10ClF3N2O3
Formula Weight
370.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.3 mg/mlEthanol: 3 mg/ml
λmax
280 nm
SMILES
O=C1OC(C2=CC=C(C(F)(F)F)C=C2)=NN1CC3=C(O)C=CC(Cl)=C3
InChi Code
InChI=1S/C16H10ClF3N2O3/c17-12-5-6-13(23)10(7-12)8-22-15(24)25-14(21-22)9-1-3-11(4-2-9)16(18,19)20/h1-7,23H,8H2
InChi Key
QKOWACXSXTXRKA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $99

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    10 mg

    $189

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    25 mg

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    50 mg

    $781

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    Product Description

    BMS 191011 is an activator of large-conductance calcium-activated potassium (KCa1.1/BK) channels that increases maximum potassium current to 126% of control in X. laevis oocytes expressing human KCa1.1 channels when used at a concentration of 1 μM.1 In vivo, BMS 191011 (10-100 μg/kg, i.v.) increases the diameter of retinal arterioles without affecting blood pressure or heart rate in rats, an effect that is reversed by the KCa1.1 channel blocker iberiotoxin (Item No. 14608).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Romine, J.L., Martin, S.W., Meanwell, N.A., et al. 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: Opener of large-conductance Ca2+-activated potassium (maxi-K) channels, identification, solubility, and SAR. J. Med. Chem. 50(3), 528-542 (2007).

    2. Mori, A., Suzuki, S., Sakamoto, K., et al. BMS-191011, an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo. Biol. Pharm. Bull. 34(1), 150-152 (2011).