An indirect activator of STING signaling
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G10

Item No. 22353

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(2-chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide
CAS Number
702662-50-8
Synonyms
  • STING Agonist-1
Molecular Formula
C21H16ClFN2O3S
Formula Weight
430.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 0.5 mg/ml
λmax
253, 292 nm
SMILES
O=C1CSC2=C(C=C(C(NCC3=CC=CO3)=O)C=C2)N1CC4=C(Cl)C=CC=C4F
InChi Code
InChI=1S/C21H16ClFN2O3S/c22-16-4-1-5-17(23)15(16)11-25-18-9-13(6-7-19(18)29-12-20(25)26)21(27)24-10-14-3-2-8-28-14/h1-9H,10-12H2,(H,24,27)
InChi Key
NAGKYJATVFXZKN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    G10 is an indirect activator of stimulator of interferon genes (STING) signaling.1 It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC90s = 8.01 and 24.57 µM, respectively). G10 (100 µM) increases phosphorylation of IRF3, which is lost in cells lacking STING.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sali, T.M., Pryke, K.M., Abraham, J., et al. Characterization of a novel human-specific STING agonist that elicits antiviral activity against emerging alphaviruses. PLoS Pathog. 11(12), e1005324 (2015).