An inhibitor of the PD-1/PD-L1 interaction
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Biochemicals

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Cancer
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BMS-8

Item No. 22355

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[3-bromo-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylic acid
CAS Number
1675201-90-7
Molecular Formula
C27H28BrNO3
Formula Weight
494.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Methanol: slightly soluble
λmax
234 nm
SMILES
CC1=C(COC2=CC=C(CN3CCCCC3C(O)=O)C=C2Br)C=CC=C1C4=CC=CC=C4
InChi Code
InChI=1S/C27H28BrNO3/c1-19-22(10-7-11-23(19)21-8-3-2-4-9-21)18-32-26-14-13-20(16-24(26)28)17-29-15-6-5-12-25(29)27(30)31/h2-4,7-11,13-14,16,25H,5-6,12,15,17-18H2,1H3,(H,30,31)
InChi Key
QRXBPPWUGITQLE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $135

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    10 mg

    $253

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    25 mg

    $597

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    Cayman Chemical
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    Product Description

    BMS-8 is a small molecule inhibitor of the protein-protein interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) with an IC50 value of 146 nM in a homogeneous time-resolved fluorescence (HTRF) binding assay.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guzik, K., Zak, K.M., Grudnik, P., et al. Small-molecule inhibitors of the programmed cell death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction via transiently induced protein states and dimerization of PD-L1. J. Med. Chem. 60(13), 5857-5867 (2017).