An inhibitor of SIRT3
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CAY10721

Item No. 22403

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(benzofuro[3,2-d]pyrimidin-4-ylthio)-N-(3-hydroxyphenyl)-acetamide
CAS Number
848688-62-0
Molecular Formula
C18H13N3O3S
Formula Weight
351.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
λmax
211, 237, 293 nm
SMILES
O=C(NC1=CC(O)=CC=C1)CSC2=NC=NC3=C2OC4=C3C=CC=C4
InChi Code
InChI=1S/C18H13N3O3S/c22-12-5-3-4-11(8-12)21-15(23)9-25-18-17-16(19-10-20-18)13-6-1-2-7-14(13)24-17/h1-8,10,22H,9H2,(H,21,23)
InChi Key
ZXXJUSSVHKICFE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    25 mg

    $587

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    Product Description

    CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM).1 Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Salo, H.S., Laitinen, T., Poso, A., et al. Identification of novel SIRT3 inhibitor scaffolds by virtual screening. Bioorg. Med. Chem. Lett. 23(10), 2990-2995 (2013).

    2. Yan, S.M., Han, X., Han, P.J., et al. SIRT3 is a novel prognostic biomarker for esophageal squamous cell carcinoma. Med. Oncol. 31(8), (2014).

    3. Ashraf, N., Zino, S., MacIntyre, A., et al. Altered sirtuin expression is associated with node-positive breast cancer. Br. J. Cancer. 95(8), 1056-1061 (2006).