A flavonoid with anticancer and antiplasmodial activity
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

4'-O-methyl Quercetin

Item No. 22406

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
CAS Number
603-61-2
Synonyms
  • 4'-methoxy Quercetin
  • Tamarixetin
Molecular Formula
C16H12O7
Formula Weight
316.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
OC1=CC(O)=C(C(C(O)=C(C2=CC=C(OC)C(O)=C2)O3)=O)C3=C1
InChi Code
InChI=1S/C16H12O7/c1-22-11-3-2-7(4-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3
InChi Key
FPLMIPQZHHQWHN-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $54

    Add

    1 mg

    $103

    Add

    5 mg

    $324

    Add

    10 mg

    $593

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    4'-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity.1,2,3 4'-O-methyl Quercetin is a major metabolite of quercetin (Item No.10005169) that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM.1 It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4'-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy.2 4'-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nicolini, F., Burmistrova, O., Marrero, M.T., et al. Induction of G2/M phase arrest and apoptosis by the flavonoid tamarixetin on human leukemia cells. mol. Carcinog. 53(12), 939-950 (2014).

    2. Tan, K.W., Li, Y., Paxton, J.W., et al. Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2). Food Chem. 138(4), 2267-2274 (2013).

    3. Ezenyi, I.C., Salawu, O.A., Kulkarni, R., et al. Antiplasmodial activity-aided isolation and identification of quercetin-4'-methyl ether in Chromolaena odorata leaf fraction with high activity against chloroquine-resistant Plasmodium falciparum. Parasitol Res. 113(12), 4415-4422 (2014).