A fluroquinolone antibiotic
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Danofloxacin (mesylate)

Item No. 22408

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-3-quinolinecarboxylic acid, methanesulfonate
CAS Number
119478-55-6
Synonyms
  • CP 76,136-27
Molecular Formula
C19H20FN3O3 • CH3SO3H
Formula Weight
453.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/mlWater: 20 mg/ml
λmax
236, 282, 351 nm
SMILES
FC1=CC2=C(C=C1N3C[C@H]4N(C)C[C@@H]3C4)N(C5CC5)C=C(C(O)=O)C2=O.O=S(O)(C)=O
InChi Code
InChI=1S/C19H20FN3O3.CH4O3S/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10;1-5(2,3)4/h5-6,9-12H,2-4,7-8H2,1H3,(H,25,26);1H3,(H,2,3,4)/t11-,12-;/m0./s1
InChi Key
APFDJSVKQNSTKF-FXMYHANSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Danofloxacin is a fluoroquinolone antibiotic. In vitro, danofloxacin has activity against 68 field isolates of Mycoplasma species isolated from cattle, swine, and poultry with MICs ranging from 8 to 500 nM.1 It is protective in vivo against P. multocida, E. coli, and S. choleraesuis in mice with protective doses of 0.31, 0.40, and 2.42 mg/kg, respectively.2 Formulations containing danofloxacin are widely used to prevent infectious disease in livestock.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cooper, A.C., Fuller, J.R., Fuller, M.K., et al. In vitro activity of danofloxacin, tylosin and oxytetracycline against mycoplasmas of veterinary importance. Res. Vet. Sci. 54(3), 329-334 (1993).

    2. McGuirk, P.R., Jefson, M.R., Mann, D.D., et al. Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. J. Med. Chem. 35(4), 611-620 (1992).

    3. Yao, M., Gao, W., Tao, H., et al. The regulation effects of danofloxacin on pig immune stress induced by LPS. Res. Vet. Sci. 110, 65-71 (2017).