A fluoroquinolone antibiotic
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Finafloxacin (hydrochloride)

Item No. 22410

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, monohydrochloride
CAS Number
209342-41-6
Synonyms
  • BAY35-337
Molecular Formula
C20H19FN4O4 • HCl
Formula Weight
434.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
245, 286, 371 nm
SMILES
FC1=CC2=C(C(C#N)=C1N3C[C@@](NCCO4)([H])[C@]4([H])C3)N(C5CC5)C=C(C(O)=O)C2=O.Cl
InChi Code
InChI=1S/C20H19FN4O4.ClH/c21-14-5-11-17(25(10-1-2-10)7-13(19(11)26)20(27)28)12(6-22)18(14)24-8-15-16(9-24)29-4-3-23-15;/h5,7,10,15-16,23H,1-4,8-9H2,(H,27,28);1H/t15-,16-;/m0./s1
InChi Key
CQMSQUOHWYYEKM-MOGJOVFKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Finafloxacin is a fluoroquinolone antibiotic.1 It is active against S. pneumoniae and P. aeruginosa, as well as methicillin-resistant S. aureus (MRSA) that is sensitive or resistant to fluoroquinolones (MIC90s = 2, 2, 0.125, and 4 mg/L, respectively). Finafloxacin (23.1 mg/kg) improves survival in F. tularensis- or Y. pestis-infected mice in models of tularemia or plague, respectively.2 Formulations containing finafloxacin have been used in the treatment of acute otitis externa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kocsis, B., Domokos, J., and Szabo, D. Chemical structure and pharmacokinetics of novel quinolone agents represented by avarofloxacin, delafloxacin, finafloxacin, zabofloxacin and nemonoxacin. Ann. Clin. Microbiol. Antimicrob. 15(1), 34 (2016).

    2. Barnes, K.B., Richards, M.I., Laws, T.R., et al. Finafloxacin is an effective treatment for inhalational tularemia and plague in mouse models of infection. Antimicrob. Agents Chemother. 65(6), e02294-02220 (2021).