A flavonoid with diverse biological activities
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Pinostrobin

Item No. 22436

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-dihydro-5-hydroxy-7-methoxy-2S-phenyl-4H-1-benzopyran-4-one
CAS Number
480-37-5
Molecular Formula
C16H14O4
Formula Weight
270.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 12 mg/ml
λmax
213, 288 nm
SMILES
COC1=CC(O)=C(C(C[C@@H](C2=CC=CC=C2)O3)=O)C3=C1
InChi Code
InChI=1S/C16H14O4/c1-19-11-7-12(17)16-13(18)9-14(20-15(16)8-11)10-5-3-2-4-6-10/h2-8,14,17H,9H2,1H3/t14-/m0/s1
InChi Key
ORJDDOBAOGKRJV-AWEZNQCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $42

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    10 mg

    $80

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    25 mg

    $189

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    50 mg

    $313

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    Product Description

    Pinostrobin is a flavonoid with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties.1 It induces quinone reductase (QR) in murine hepatoma cells with a QR doubling concentration of 500 nM.2 Pinostrobin inhibits TNF-α and IL-1β production in RAW 264.7 macrophages (IC50s = 17.28 and 23.5 μM, respectively) and in LPS-stimulated rats (48.6 and 55% reduction, respectively).3 Pinostrobin also shows selective cytotoxicity for CCRF-CEM leukemia cells (IC50 = 10.2 μM) in a panel of eight cancer cell lines (IC50s = >30 μM).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Patel, N.K., Jaiswal, G., and Bhutani, K.K. A review on biological sources, chemistry and pharmacological activities of pinostrobin. Nat. Prod. Res. 30(18), 2017-2027 (2016).

    2. Fahey, J.W., and Stephenson, K.K. Pinostrobin from honey and thai ginger (Boesenbergia pandurata): A potent flavonoid inducer of mammalian phase 2 chemoprotective and antioxidant enzymes. J. Agric. Food Chem. 50(25), 7472-7476 (2002).

    3. Patel, N.K., and Bhutani, K.K. Pinostrobin and Cajanus lactone isolated from Cajanus cajan (L.) leaves inhibits TNF-α and IL-1 production: In vitro and in vivo experimentation. Phytomedicine 21(7), 946-953 (2014).

    4. Ashidi, J.S., Houghton, P.J., Hylands, P.J., et al. Ethnobotanical survey and cytotoxicity testing of plants of South-western Nigeria used to treat cancer, with isolation of cytotoxic constituents from Cajanus cajan Millsp. leaves. J. Ethnopharmacol. 128(2), 501-512 (2010).