An activator of the RLR pathway
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KIN1400

Item No. 22441

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[(2-benzothiazolylamino)[4-(difluoromethoxy)phenyl]methyl]-8-quinolinol
CAS Number
446826-86-4
Molecular Formula
C24H17F2N3O2S
Formula Weight
449.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/mlEthanol: 1 mg/ml
SMILES
FC(F)OC(C=C1)=CC=C1C(NC2=NC3=C(C=CC=C3)S2)C4=C(O)C(N=CC=C5)=C5C=C4
InChi Code
InChI=1S/C24H17F2N3O2S/c25-23(26)31-16-10-7-15(8-11-16)20(29-24-28-18-5-1-2-6-19(18)32-24)17-12-9-14-4-3-13-27-21(14)22(17)30/h1-13,20,23,30H,(H,28,29)
InChi Key
YDSHHDISKUSKFW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    KIN1400 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity.1 It induces expression of the innate immune genes RIG-1, MDA5, IFIT1, IFIT2, IFITM1, OAS3, and Mx1 in THP-1 cells stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014). KIN1400 (20 μM) reduces West Nile and dengue viral RNA levels in HEK293 and Huh7 cells, respectively. It also inhibits hepatitis C virus (HCV) replication in a concentration-dependent manner in Huh7 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pattabhi, S., Wilkins, C.R., Dong, R., et al. Targeting innate immunity for antiviral therapy through small molecule agonists of the RLR pathway. J. Virol. 90(5), 2372-2387 (2015).