An inhibitor of protein tyrosine phosphatases
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TPI-1

Item No. 22480

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2,5-dichlorophenyl)-2,5-cyclohexadiene-1,4-dione
CAS Number
79756-69-7
Synonyms
  • Tyrosine Phosphatase Inhibitor 1
Molecular Formula
C12H6Cl2O2
Formula Weight
253.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/ml
λmax
229 nm
SMILES
ClC1=C(C(C(C=C2)=O)=CC2=O)C=C(Cl)C=C1
InChi Code
InChI=1S/C12H6Cl2O2/c13-7-1-3-11(14)9(5-7)10-6-8(15)2-4-12(10)16/h1-6H
InChi Key
ZKHFYORNAYYOTM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $312

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    25 mg

    $631

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    Cayman Chemical
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    Product Description

    TPI-1 is an inhibitor of protein tyrosine phosphatases.1 TPI-1 (10 ng/ml) increases phosphorylated substrates of the phosphatase SHP-1 in Jurkat T cells, including pLck-pY394, pZap70, and pSlp76. It is selective for SHP-1 over SHP-2, having low activity at the SHP-2 substrate pERK1/2. It increases pLck-pY394 levels by approximately 3.3-fold and increases the number of IFN-γ+ cells in mouse spleen ex vivo following a dose of approximately 3 mg/kg. Oral administration of TPI-1 (3 mg/kg per day) inhibits tumor growth in a B16 melanoma mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kundu, S., Fan, K., Cao, M., et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J. Immunol. 184(11), 6529-6536 (2010).