An inhibitor of the MITF pathway
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Death
Transcription Factors

ML-329

Item No. 22481

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-benzenesulfonamide
CAS Number
19992-50-8
Molecular Formula
C16H12N2O4S
Formula Weight
328.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 0.1 mg/ml
λmax
202, 281, 455 nm
SMILES
O=C1C(NC2=CC=C(S(N)(=O)=O)C=C2)=CC(C3=CC=CC=C31)=O
InChi Code
InChI=1S/C16H12N2O4S/c17-23(21,22)11-7-5-10(6-8-11)18-14-9-15(19)12-3-1-2-4-13(12)16(14)20/h1-9,18H,(H2,17,21,22)
InChi Key
CSYFFQVEQXEIAB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $38

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    5 mg

    $160

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    10 mg

    $283

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    Cayman Chemical
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    Product Description

    ML-329 is an inhibitor of the microphthalmia-associated transcription factor (MITF) pathway with an IC50 value of 1.2 μM for promoter activity of the MITF target gene TRPM-1.1 It is selectively cytotoxic to the SK-MEL-5 and MALME-3M MITF-dependent melanoma cell lines over A375 MITF-independent cells (IC50s = 0.1, 0.7, and 70 μM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Faloon, P.W., Bennion, M., Weiner, W.S., et al. A small molecule inhibitor of the MITF molecular pathway. Probe Reports from the NIH Molecular Libraries Program (2012).