A bioactive sphingolipid
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C10 Ceramide (d18:1/10:0)

Item No. 22529

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-decanamide
CAS Number
111122-57-7
Synonyms
  • Cer(d18:1/10:0)
  • C10 Ceramide
  • Ceramide (d18:1/10:0)
  • N-decanoyl-D-erythro-Sphingosine
Molecular Formula
C28H55NO3
Formula Weight
453.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 0.50 mg/ml
SMILES
OC[C@H](NC(CCCCCCCCC)=O)[C@H](O)/C=C/CCCCCCCCCCCCC
InChi Code
InChI=1S/C28H55NO3/c1-3-5-7-9-11-12-13-14-15-16-18-19-21-23-27(31)26(25-30)29-28(32)24-22-20-17-10-8-6-4-2/h21,23,26-27,30-31H,3-20,22,24-25H2,1-2H3,(H,29,32)/b23-21+/t26-,27+/m0/s1
InChi Key
FDWVAQFAMZLCAX-NBNLIBPQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $91

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    Product Description

    C10 ceramide is an endogenous, bioactive sphingolipid produced by ceramide synthase.1 C10 ceramide inhibits growth of wild-type and MDR1 gene-transfected MDA435/LCC6 human breast cancer cells with IC50 values of 44.1 and 46 μM, respectively. It also inhibits the growth of J774 murine macrophages in a dose-dependent manner. [Matreya, LLC. Catalog No. 1333]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shabbits, J.A., and Mayer, L.D. Intracellular delivery of ceramide lipids via liposomes enhances apoptosis in vitro. Biochim. Biophys. Acta 1612(1), 98-106 (2003).