An internal standard for the quantification of bazedoxifene
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Bazedoxifene-d4

Item No. 22554

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy-1,1,2,2-d4]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
CAS Number
1133695-49-4
Molecular Formula
C30H30D4N2O3
Formula Weight
474.6
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
CC1=C(C2=CC=C(O)C=C2)N(CC3=CC=C(OC([2H])([2H])C([2H])([2H])N4CCCCCC4)C=C3)C5=C1C=C(O)C=C5
InChi Code
InChI=1S/C30H34N2O3/c1-22-28-20-26(34)12-15-29(28)32(30(22)24-8-10-25(33)11-9-24)21-23-6-13-27(14-7-23)35-19-18-31-16-4-2-3-5-17-31/h6-15,20,33-34H,2-5,16-19,21H2,1H3/i18D2,19D2
InChi Key
UCJGJABZCDBEDK-AUZVCRNNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Bazedoxifene-d4 is intended for use as an internal standard for the quantification of bazedoxifene (Item No. 15005) by GC- or LC-MS. Bazedoxifene is a third generation selective estrogen receptor modulator (SERM). It is an indole-based ER ligand that binds to both ERα (IC50 = 26 nM) and ERβ (IC50 = 99 nM).1 Bazedoxifene antagonizes 17β-estradiol-dependent MCF-7 and T47D breast cancer cell proliferation in vitro as well as hormone-independent growth of MCF-7:5C cells that are resistant to long-term estrogen deprivation (80% reduction with 10 nM).2 It has been shown to arrest cell cycling by downregulating cyclin D1 and ERα.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Komm, B.S., Kharode, Y.P., Bodine, P.V.N., et al. Bazedoxifene acetate: A selective estrogen receptor modulator with improved selectivity. Endocrinology 146(9), 3999-4008 (2005).

    2. Lewis-Wambi, J.S., Kim, H., Curpan, R., et al. The selective estrogen receptor modulator bazedoxifene inhibits hormone-independent breast cancer cell growth and down-regulates estrogen receptor α and cyclin D1. Mol. Pharmacol. 80(4), 610-620 (2011).