An internal standard for the quantification of tolperisone
Related Products
Unlabeled Version(s)
26078Tolperisone (hydrochloride)
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Tolperisone-d10 (hydrochloride)

Item No. 22592

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-2,2,3,3,4,4,5,5,6,6-decadeuteriopiperidin-1-yl)-2-methyl-1-(4-methylphenyl)propan-1-one, monohydrochloride)
CAS Number
1185160-65-9
Molecular Formula
C16H13D10NO • HCl
Formula Weight
291.9
Purity
≥99% deuterated forms (d1-d10)
Formulation
A solid
SMILES
CC1=CC=C(C(C(CN2C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C2([2H])[2H])C)=O)C=C1.Cl
InChi Code
InChI=1S/C16H23NO.ClH/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17;/h6-9,14H,3-5,10-12H2,1-2H3;1H/i3D2,4D2,5D2,10D2,11D2;
InChi Key
ZBUVYROEHQQAKL-XVKVVLOSSA-N
Shipping & Storage Information
Storage
2°C to 8°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $169

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    Product Description

    Tolperisone-d10 is intended for use as an internal standard for the quantification of tolperisone by GC- or LC-MS. Tolperisone is a piperidine that acts as an inhibitor of voltage-gated sodium channels with an IC50 value of 198 µM, for inhibition of peak sodium currents evoked by step depolarizations in dorsal root ganglion (DRG) neurons, in vitro.1 Tolperisone acts as an antispastic agent that attenuates monosynaptic, disynaptic, and polysynaptic reflux response to dorsal root stimulation in vivo. Formulations containing tolperisone are used as analgesics and muscle relaxants.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kocsis, P., Farkas, S., Fodor, L., et al. Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J. Pharmacol. Exp. Ther. 315(3), 1237-1246 (2005).