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3-Trifluoromethylamphetamine (hydrochloride)

Item No. 22604

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • desethyl Fenfluramine
  • (±)-Norfenfluramine
Technical Information
Formal Name
α-methyl-3-(trifluoromethyl)-benzeneethanamine, monohydrochloride
CAS Number
673-18-7
Molecular Formula
C10H12F3N • HCl
Formula Weight
239.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
NC(C)CC1=CC(C(F)(F)F)=CC=C1.Cl
InChi Code
InChI=1S/C10H12F3N.ClH/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13;/h2-4,6-7H,5,14H2,1H3;1H
InChi Key
PIDLOFBRTWNFAR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    3-Trifluoromethylamphetamine (hydrochloride) ( Item No. 22604) is an analytical reference standard that is categorized as an amphetamine. It is an active metabolite of fenfluramine and benfluorex that acts as an agonist at serotonin (5-HT) receptors (IC50s = 6.92, 3.55, 0.17, and 2.09 µM for 5-HT1A, 5-HT1B, 5-HT1C, and 5-HT2 receptors, respectively, in murine brain).1,2 Norfenfluramine induces anorexia in mice and rats with EC50 values of 6.8 and 0.8 mg/kg, i.p., respectively.1 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mennini, T., Bizzi, A., Caccia, S., et al. Comparative studies on the anorectic activity of d-fenfluramine in mice, rats, and guinea pigs. Naunyn-Schmiedeberg's Arch. Pharmacol. 343(5), 483-490 (1991).

    2. Curzon, G., Gibson, E.L., and Oluyomi, A.O. Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability. Trends Pharmacol. Sci. 18(1), 21-25 (1997).