A BKCa channel blocker
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GAL-021

Item No. 22609

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-methoxy-N2-methyl-N4,N6-dipropyl-1,3,5-triazine-2,4,6-triamine
CAS Number
1380341-99-0
Molecular Formula
C11H22N6O
Formula Weight
254.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.30 mg/ml
SMILES
CN(OC)C1=NC(NCCC)=NC(NCCC)=N1
InChi Code
InChI=1S/C11H22N6O/c1-5-7-12-9-14-10(13-8-6-2)16-11(15-9)17(3)18-4/h5-8H2,1-4H3,(H2,12,13,14,15,16)
InChi Key
FJNLCHNQVJVCPY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

    $190

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    10 mg

    $306

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    25 mg

    $587

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    Product Description

    GAL-021 is a large-conductance Ca2+-activated potassium channel (BKCa/KCa1.1) blocker.1 It inhibits BKCa single-channel activity in GH3 cells in a concentration-dependent manner when used at concentrations ranging from 1 to 10 μM. GAL-021 increases respiratory product minute volume in wild-type rats and mice (ED50s = 0.1 and 0.5 mg/kg) but not mice with bilaterally transected carotid sinus nerves or Slo-/- mice that lack the pore-forming α-subunit of BKCa. It reverses morphine-induced respiratory depression in rats and cynomolgus monkeys. GAL-021 also potentiates morphine-induced analgesia in a tail-flick assay in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Golder, F.J., Dax, S.L., Baby, S.M., et al. Identification and characterization of GAL-021 as a novel breathing control modulator. Anesthesiology 123(5), 1093-1104 (2015).