A BKCa channel blocker
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

GAL-021

Item No. 22609

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-methoxy-N2-methyl-N4,N6-dipropyl-1,3,5-triazine-2,4,6-triamine
CAS Number
1380341-99-0
Molecular Formula
C11H22N6O
Formula Weight
254.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.30 mg/ml
SMILES
CN(OC)C1=NC(NCCC)=NC(NCCC)=N1
InChi Code
InChI=1S/C11H22N6O/c1-5-7-12-9-14-10(13-8-6-2)16-11(15-9)17(3)18-4/h5-8H2,1-4H3,(H2,12,13,14,15,16)
InChi Key
FJNLCHNQVJVCPY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $49

    Add

    5 mg

    $190

    Add

    10 mg

    $306

    Add

    25 mg

    $587

    Add
    Product Description

    GAL-021 is a large-conductance Ca2+-activated potassium channel (BKCa/KCa1.1) blocker.1 It inhibits BKCa single-channel activity in GH3 cells in a concentration-dependent manner when used at concentrations ranging from 1 to 10 μM. GAL-021 increases respiratory product minute volume in wild-type rats and mice (ED50s = 0.1 and 0.5 mg/kg) but not mice with bilaterally transected carotid sinus nerves or Slo-/- mice that lack the pore-forming α-subunit of BKCa. It reverses morphine-induced respiratory depression in rats and cynomolgus monkeys. GAL-021 also potentiates morphine-induced analgesia in a tail-flick assay in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Golder, F.J., Dax, S.L., Baby, S.M., et al. Identification and characterization of GAL-021 as a novel breathing control modulator. Anesthesiology 123(5), 1093-1104 (2015).