A cereblon modulator
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Iberdomide

Item No. 22615

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3S-[1,3-dihydro-4-[[4-(4-morpholinylmethyl)phenyl]methoxy]-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
CAS Number
1323403-33-3
Synonyms
  • CC-220
Molecular Formula
C25H27N3O5
Formula Weight
449.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mlDMSO: 12 mg/mlDMSO:PBS (pH 7.2) (1:8): 0.11 mg/ml
λmax
284 nm
SMILES
O=C1C2=CC=CC(OCC3=CC=C(CN4CCOCC4)C=C3)=C2CN1[C@@H]5C(NC(CC5)=O)=O
InChi Code
InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1
InChi Key
IXZOHGPZAQLIBH-NRFANRHFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    25 mg

    $587

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    Product Description

    Iberdomide is a modulator of cereblon, a substrate receptor in the CRL4 ubiquitin ligase complex, that has an IC50 value of 60 nM in a competitive TR-FRET assay.1 In the same assay, it has a higher affinity for cereblon than the related modulators lenalidomide (Item No. 14643; IC50 = 1,500 nM) and pomalidomide (Item No. 19877; IC50 = 1,200 nM). Iberdomide also has a greater potency for degrading the CRL4 complex substrates Ikaros and Aiolos (EC50s = 1 and 0.5 nM) but has no degradative activity for GSPT1 or CK1α.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matyskiela, M.E., Zhang, W., Man, H.W., et al. A cereblon modulator (CC-220) with improved degradation of Ikaros and Aiolos. J. Med. Chem. (2017).