HX 1171

HX 1171 is a derivative of vitamin E that has lipid peroxidative, antioxidant, and cancer-related activities.^1,2,3 It inhibits lipid peroxidation by 98 and 40% when used at concentrations of 10 and 1 µM, respectively, in rat liver microsomes.¹ It activates NRF2 by enhancing its nuclear translocation and transcriptional activity, increasing the expression of the antioxidant-related enzymes NQO1 and HMOX1 in A549 human lung epithelial cells.⁴ HX 1171 (30 mg/kg) reduces the amount of fibrosis and the level of fibrotic markers in liver and primary hepatocytes, respectively, from rats with carbon tetrachloride-induced liver cirrhosis.² It also decreases the incidence of hepatocellular adenomas and hemangiosarcomas in rats treated with the aminopyrine (AP) and sodium nitrite (NaNO₂), but increases the incidence of forestomach carcinoma when administered with AP and NaNO₂ or NaNO₂ alone.³

WARNING This product is not for human or veterinary use.

1. Nihro, Y., Furukawa, H., Sogawa, S., et al. Synthesis and anti lipid-peroxidation activity of hydroquinone monoalkyl ethers. Chem. Pharm. Bull. (Tokyo) 42(3), 576-579 (1994).

2. An, J., Feng, G.G., Huang, L., et al. Effects of 1-O-hexyl-2,3,5-trimethylhydroquinone on carbon tetrachloride-induced hepatic cirrhosis in rats. Hepatol. Res. 40(6), 613-621 (2010).

3. Yada, H., Hirose, M., Tamano, S., et al. Effects of antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone or ascorbic acid on carcinogenesis induced by administration of aminopyrine and sodium nitrite in a rat multi-organ carcinogenesis model. Jpn. J. Cancer Res. 93(12), 1299-1307 (2002).

4. Kim, J., Shin, S.H., Ko, Y.E., et al. HX-1171, a novel Nrf2 activator, induces NQO1 and HMOX1 expression. J. Cell. Biochem. 118(10), 3372-3380 (2017).