Active E. coli (strain K12)
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Succinyl-CoA synthetase

Item No. 22673

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • SCS
  • Succinate Thiokinase
  • Succinyl Coenzyme A Synthetase
Purity
≥85% estimated by SDS-PAGE
Source
Active E. coli (strain K12) C-terminal His-tagged Succinyl-CoA synthetase enzyme purified from E. coli
MW
29.8 kDa (α), 41.4 kDa (β)
Formulation (Request formulation change)
50 mM HEPES, pH 8.0, 150 mM sodium chloride, 20% glycerol
UniProt Accession №
P0A836, P0AGE9
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $267

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    1 mg

    $1,062

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    Product Description

    Succinyl-CoA synthetase from E. coli is responsible for the coupled hydrolysis of succinyl-CoA to the production of ATP (or GTP) in the substrate-level phosphorylation step of the citric acid cycle (TCA).1 This enzyme complex is formed as a heterotetramer, α2β2, where the two α subunits each contain the coenzyme A and phosphate binding sites, and the two β subunits each contain the succinate binding sites and provide nucleotide binding specificity. This enzyme is Mg2+-dependent.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Joyce, M.A., Fraser, M.E., Brownie, E.R., et al. Probing the nucleotide-binding site of Escherichia coli succinyl-CoA synthetase. Biochemistry 38(22), 7273-7283 (1999).