An internal standard for the quantification of 1-arachidonoyl glycerol
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Alternative(s)
3621521-Arachidonoyl-d5-rac-glycerol
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1-Arachidonoyl-d8-rac-glycerol

Item No. 22694

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5Z,8Z,11Z,14Z-eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid, 2,3-dihydroxypropyl ester
CAS Number
2692624-29-4
Synonyms
  • 1-AG-d8
Molecular Formula
C23H30D8O4
Formula Weight
386.6
Purity
≥99% deuterated forms (d1-d8)
Formulation
A 1 mg/ml solution in acetonitrile
Solubility(Learn about Variance in Solubility)
DMSO: 2 mg/mlEthanol: misciblePBS (pH 7.2): 0.1 mg/ml
SMILES
O=C(OCC(CO)O)CCC/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\CCCCC
InChi Code
InChI=1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-21-22(25)20-24/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-/i6D,7D,9D,10D,12D,13D,15D,16D
InChi Key
DCPCOKIYJYGMDN-FBFLGLDDSA-N
Side Chain Carbon Sum
20:4
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    Product Description

    1-Arachidonoyl-d8-rac-glycerol (1-AG-d8) is intended for use as an internal standard for the quantification of 1-AG (Item No. 62150) by GC- or LC-MS. 1-AG is a weak cannabinoid (CB1) receptor agonist and may have other pharmacologic properties.1 1-AG is an isomer of 2-AG. 2-AG is chemically unstable and undergoes rapid isomerization to 1-AG (synonymous with 1(3)-AG) both in vitro and in vivo. 1-AG is a frequent contaminant in synthetic 2-AG preparations, and can markedly reduce their cannabinergic potency.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sugiura, T., Kodaka, T., Kondo, S., et al. Is the cannabinoid CB1 receptor a 2-arachidonoylglycerol receptor? Structural requirements for triggering a Ca2+ transient in NG108-15 cells. J. Biochem. 122(4), 890-895 (1997).