A probe to detect H2S in mitochondria
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MitoA

Item No. 22702

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3-(4-azidobenzamido)propyl)triphenylphosphonium, monobromide
Molecular Formula
C28H26N4OP • Br
Formula Weight
545.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
λmax
269 nm
SMILES
O=C(C1=CC=C(N=[N+]=[N-])C=C1)NCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Br-]
InChi Code
InChI=1S/C28H25N4OP.BrH/c29-32-31-24-19-17-23(18-20-24)28(33)30-21-10-22-34(25-11-4-1-5-12-25,26-13-6-2-7-14-26)27-15-8-3-9-16-27;/h1-9,11-20H,10,21-22H2;1H
InChi Key
ZRHGIBLKBREUQK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $61

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    5 mg

    $273

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    10 mg

    $484

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    25 mg

    $1,060

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    Product Description

    MitoA is a ratiometric mass spectrometry probe that can be used for assessing changes in H2S within mitochondria in vivo.1 MitoA contains a triphenylphosphonium cation component that drives its accumulation in mitochondria where its aryl azide moiety selectively reacts with H2S to produce an amine product, MitoN. Quantifying the MitoN/MitoA ratio by LC-MS/MS reflects the mitochondrial matrix H2S concentration. In a mouse model of acute myocardial infarction with MitoA administered prior to ischemia, the MitoN/MitoA ratio is increased only in the region of ischemia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Arndt, S., Baeza-Garza, C.D., Logan, A., et al. Assessment of H2S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA. The Journal of Biological Chemisty 292(19), 7761-7773 (2017).