An antioxidant
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Lecanoric Acid

Item No. 22710

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-dihydroxy-6-methyl-benzoic acid, 4-carboxy-3-hydroxy-5-methylphenyl ester
CAS Number
480-56-8
Synonyms
  • NSC 249981
Molecular Formula
C16H14O7
Formula Weight
318.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
CC1=CC(OC(C2=C(C)C=C(O)C=C2O)=O)=CC(O)=C1C(O)=O
InChi Code
InChI=1S/C16H14O7/c1-7-3-9(17)5-11(18)14(7)16(22)23-10-4-8(2)13(15(20)21)12(19)6-10/h3-6,17-19H,1-2H3,(H,20,21)
InChi Key
HEMSJKZDHNSSEW-UHFFFAOYSA-N
Origin
Fungus/Parmotrema sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    Product Description

    Lecanoric acid is a naturally occurring depside polyphenol isolated from a variety of lichens.1 It is a potent antioxidant, surpassing ascorbic acid in a 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) free radical scavenging assay (IC50s = 424.51 and 6.42 μg/ml for lecanoric and ascorbic acid, respectively).2 Lecanoric acid has antibacterial and antifungal activities with minimum inhibitory concentrations ranging from 0.5 to 1 mg/ml for a panel of fifteen microorganisms. In a cell viability assay, lecanoric acid exhibits antiproliferative activity against HeLa cells (IC50 = 123.97 μg/ml). Lecanoric acid also exhibits antidiabetic and hypolipidemic properties.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thadhani, V.M., and Karunaratne, V. Potential of lichen compounds as antidiabetic agents with antioxidative properties: A review. Oxid. Med. Cell. Longev. 2017, (2017).

    2. Ristić, S., Ranković, B., Kosanić, M., et al. Phytochemical study and antioxidant, antimicrobial and anticancer activities of Melanelia subaurifera and Melanelia fuliginosa lichens. J. Food. Sci. Technol. 53(6), 2804-2816 (2016).

    3. Wei, A.-H., Zhou, D.-N., Ruan, J.-L., et al. Characterisation of phenols and antioxidant and hypolipidaemic activities of Lethariella cladonioides. J. Sci. Food Agric. 92(2), 373-379 (2012).